Ion Mobility Spectrometry and REIMS Direct-from-sample Ionization
Deliver Greater Clarity, Confidence and Speed to Routine LC-MS and MS
Analyses
MILFORD, Mass.--(BUSINESS WIRE)--May 27, 2015--
Waters
Corporation (NYSE:WAT) at the 63rd conference of the
Society of Mass Spectrometry announced the introduction of new
technologies and innovations for mass spectrometry, intended to give
laboratories greater levels of detail for every analysis.
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Waters New Vion IMS QTof Mass Spectrometer (Photo: Business Wire)
The introductions include the new Waters®
Vion IMS QTof Mass Spectrometer, a new bench-top tandem mass
spectrometer featuring ion mobility and REIMS Research System with
iKnife Sampling, combining direct-from-sample ionization with
high-performance time-of-flight (ToF) mass spectrometry.
Waters also expanded its family of solid phase extraction products with
the first-of-its-kind Oasis
PRiME HLB and added to its portfolio of protein separation columns
with the ACQUITY UPLC® Glycoprotein BEH Amide Column for
glycan analysis.
Vion IMS QTof Mass Spectrometer
Combining the benefits of
high-resolution tandem mass spectrometry and ion mobility separation in
a bench top instrument, the Waters®
Vion IMS QTof Mass Spectrometer brings clarity and confidence to
routine analyses. Ion mobility removes spectral interferences and
generates collision cross-section (CCS) values for every ion, giving
scientists more information than they can get from traditional LC-MS
experiments. Waters intends to commence shipments of the Vion IMS QTof
Mass Spectrometer in the second half of this year.
“More than a decade of experience in ion mobility has gone into the
design of our Vion IMS QTof instrument. For scientists involved in
sample screening, metabolite identification, or classical ‘omics
experiments, their ability to detect and identify all sample analytes in
single analysis at the bench has reached a new level,” said Gary
Harland, Director, Mass Spectrometry Product Management, Waters
Division. “Regardless of how many analytes there are in a sample, and
regardless of the concentrations which they are present in, Vion IMS
QTof empowers laboratories to respond better to analytical challenges
and succeed in meeting their scientific and business objectives.”
As routine analyses involve increasingly complex samples, scientists
often rely on high-resolution mass spectrometry. However, increasing
mass resolution alone does not always lead to better answers. By
separating ions from one another based on their shape, mass and charge,
ion mobility provides an additional dimension of separation. The
selectivity of ion mobility refines spectra and allows the instrument to
discriminate sample ions from chromatographically co-eluting compounds
and background interferences - bringing clarity to every spectrum, and
enabling the confident characterization of compounds.
UNIFI Scientific Information System Software
The UNIFI®
Scientific Information System, Version 1.8, is a new release of the
software with features intended to enhance laboratory productivity.
Today's announcement coincides with the introduction of the Vion™ IMS
QTof Mass Spectrometer which is the first Waters mass spectrometer to be
fully supported on UNIFI.
New features of this release of UNIFI software include: Support of the
Vion IMS QTof MS System; native atmospheric pressure gas chromatography
(APGC) control, time-of-flight (Tof) multiple reaction monitoring (MRM)
support, support of collision cross section (CCS) data, and Tof
quantitative and qualitative workflows providing a comprehensive, single
software solution.
REIMS Research System with iKnife Sampling
Combining
direct-from-sample ionization with high performance time-of-flight mass
spectrometry and powerful, intuitive analytics, the Rapid Evaporative
Ionization Mass Spectrometry™ (REIMS™) Research System with iKnife™
Sampling System eliminates the need for sample preparation and
chromatographic separation, providing food, microbiology and tissue
researchers with near-instantaneous data acquisition.
Using Waters REIMS Research System with iKnife Sampling, researchers can
quickly and easily differentiate samples from one another and
confidently identify the differentiating features, allowing greater
insight into the chemical and biological systems under investigation. In
REIMS, direct, rapid heating of the samples leads to the formation of
vapor that is rich in sample-specific chemical information. The vapor is
taken directly into the mass spectrometer (Xevo® G2-XS QTof
or SYNAPT® G2-Si HDMS) where the molecules are analyzed by
time-of-flight mass spectrometry.
“The new system will deliver REIMS technology into the hands of many
more scientists working in important areas such as research into food
fraud and adulteration, where we anticipate its impact could be
game-changing”, said Brian Smith, Vice President of Mass Spectrometry
Operations at Waters.
Oasis PRiME HLB
The
Oasis® PRiME HLB, a first-of-its-kind, next-generation
solid phase extraction (SPE) product that provides cleaner samples in
less time and with less effort for LC and LC-MS analyses. Oasis PRiME
HLB cartridges and multiwell plates simplify and speed up extraction
protocols to ensure consistent, reproducible LC and LC-MS results.
Laboratories can now process samples up to 40% faster and deliver
samples that are up to 70% cleaner with fewer LC-MS matrix effects than
samples prepared using other extraction techniques. Oasis PRiME HLB
Sorbent is available immediately worldwide.
“Whether doing bioanalysis, food analysis or forensic toxicological
screening by LC and LC-MS, few things are more important to getting
quality analytical results than a clean sample. That is why today’s
scientists need three things from a sample preparation protocol –
simplicity, speed, and cleaner eluates,” said Mike Yelle, Vice
President, Consumables Business Unit, Waters Division. “For scientists
working with samples containing proteins, fats or lipids, Oasis PRiME
HLB fulfills all three requirements and is now the gold standard for
solid phase extraction.”
HILIC-based Glycoprotein Column
The new ACQUITY UPLC®
Glycoprotein BEH Amide 300Å 1.7-µm Column enables biopharmaceutical
companies to better understand where glycan molecules are located within
the therapeutic proteins they are developing. Identifying the precise
location of glycans within a protein structure is essential to
delivering safe and effective biotherapeutic proteins.
The novel, patent-pending ACQUITY UPLC BEH Amide technology, assists
scientists in obtaining reproducible glycan-related chromatographic and
mass spec information at the intact protein, fragment, or peptide
levels. Designed to be used with Waters ACQUITY UPLC systems, this new
glycoprotein analysis column provides unprecedented resolution using
MS-compatible HILIC separations. Laboratories can now resolve different
glycoproteins and glycopeptides, determine where both N-linked and
O-linked glycans are located within the protein, as well as better
understand glycan modifications and patterns. Combining these
capabilities with mass spectrometric analysis provides far greater
information about glycoprotein structure than has been previously
available.
“Waters has been leading the way in innovative solutions for glycan
analysis to help our biopharmaceutical customers solve the challenges
they face with their traditional glycan workflows. The new ACQUITY UPLC
Glycoprotein BEH Amide Column, joins a family of market leading
disruptive technologies, including our Biopharmaceutical
Platform Solution with UNIFI® for characterization, and
our most recent GlycoWorks™
RapiFluor-MS™ N-Glycan sample preparation kits,” said Mike
Yelle, Vice President of Waters’ Consumable Business Unit.
About Waters Corporation (www.waters.com)
For
more than 50 years, Waters Corporation has created business advantages
for laboratory-dependent organizations by delivering practical and
sustainable innovation to enable significant advancements in such areas
as healthcare delivery, environmental management, food safety, and water
quality, consumer products and high-value added chemicals worldwide.
Pioneering a connected portfolio of separations science, laboratory
information management, mass spectrometry and thermal analysis, Waters
technology breakthroughs and laboratory solutions provide an enduring
platform for customer success.
With revenue of $1.99 billion in 2014, Waters is driving scientific
discovery and operational excellence for customers worldwide.
View source version on businesswire.com: http://www.businesswire.com/news/home/20150527005242/en/
Source: Waters Corporation
Waters Corporation
Chris Orlando, 508-482-2623
Public
Relations Manager
Chris_Orlando@waters.com