Waters MS Technology Researchers Bob Bateman and John Hoyes
Recognized at HUPO World Congress with Science and Technology Award
TAIPEI, Taiwan--(BUSINESS WIRE)--Sep. 19, 2016--
Waters Corporation (NYSE: WAT) introduces a new data acquisition mode, SONAR™,
for its Xevo® G2-XS quadrupole time-of-flight (QTof) mass
spectrometer (MS) that provides MS/MS data from data-independent
acquisitions (DIA). The technology enables analytical scientists to be
more efficient in the laboratory and have more confidence in the results
they generate. SONAR data allows for the quantification and
identification of lipids, metabolites, and proteins in complex samples
from a single injection without additional method development normally
associated with MS/MS analysis.
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The novel MS acquisition mode was announced at the 15th
annual Human Proteome Organization (HUPO) World Congress, where Bob
Bateman and John Hoyes, senior MS technology experts at Waters
Corporation, are being recognized for advancing mass spectrometry
instrumentation.
In modern proteomics experiments, DIA-based mass spectrometry has been a
popular technique for capturing data-rich sample profiles. As proteomics
and lipidomics capabilities have progressed, scientists seek to further
focus experiments to quantify specific peptides and proteins, which has
required additional method development and repeated assays. The newly
introduced SONAR data acquisition mode provides additional clarity and
information for increasingly complex samples.
“Today, as proteomics research has matured, scientists are already
collecting the majority of the information available from proteins. What
they want to be able to do is approach a protein or specific peptides
with a hypothesis, and use targeted MS/MS quantification to investigate
their ideas without setting up additional methods or experiments,” said
David Heywood, senior manager, Omics business development at Waters
Corporation. “Now, with SONAR data acquisition, they can perform a more
selective all-in-one analysis. Compatible with high-speed UPLC
separations, it’s a more efficient workflow for more accurate
qualitative and quantitative analysis within a single injection.”
Waters Scientists Recognized at HUPO
Also at the annual HUPO meeting, Waters Corporation’s Consultant for
Technical Research, Bob Bateman, and MS Technical Director and
Scientific Fellow, John Hoyes, are being recognized for their
contributions to advancing technology for proteomics research with the HUPO
Industrial Advisory Board Science and Technology Award for the
development of the Q-Tof mass spectrometer.
“The availability of a Q-Tof tandem MS instrument had tremendous
influence on the development of proteomics in its early days, since this
type of mass spectrometer coupled with a nanoLC provided unprecedented
performance in analyzing a proteome,” noted the HUPO Executive Committee
in their award announcement. The Waters® (Micromass®)
Q-Tof™ Mass Spectrometer was first commercially introduced in 1996 and
has undergone many technological advancements, most recently with the
integration of ion mobility separations and now with its novel SONAR MS
data acquisition mode.
SONAR Enhancements to MS Data Acquisition Modes
The additional selectivity offered by the SONAR data acquisition mode is
due to the behavior of the mass spectrometer’s quadrupole. Instead of
remaining open and transmitting all ions, in SONAR mode the quadrupole
slides over the selected mass range of interest, with each scan
capturing 200 spectra. The operation of the quadrupole makes the SONAR
mode compatible with fast UltraPerformance LC® (UPLC®)
separations that increase laboratory throughput. Compounds that may have
chromatographically coeluted are now separated by the quadrupole and
recorded individually for more effective library searches. The SONAR
data acquisition mode collects both quantitative and qualitative data
within a single injection.
SONAR technology is the subject of several
talks at HUPO World Congress, taking place Sept. 18-22 at the Taipei
International Convention Center.
SONAR data is compatible with analytical workflows that utilize Waters Progenesis®
and Symphony™
software, and with third-party software packages such as Skyline. SONAR
is available on the Waters Xevo
G2-XS QTof Mass Spectrometer under MassLynx®
Software control.
Waters Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory dependent
organizations. For more than 50 years, the company has pioneered a
connected portfolio of separations science, laboratory information
management, mass spectrometry and thermal analysis systems.
Waters, SONAR, Xevo, Micromass, Q-Tof, UltraPerformance LC, UPLC,
Progenesis, Symphony, and MassLynx are trademarks of Waters Corporation.
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Source: Waters Corporation
Waters Corporation
Karen Haas, +1-508-482-3363
Public Relations
Karen_haas@waters.com