With more than 900 Collision Cross Section Values, Metabolic
Profiling CCS Library to Increase Researcher Confidence during
Untargeted Studies
SAN ANTONIO--(BUSINESS WIRE)--Jun. 6, 2016--
Waters Corporation (NYSE: WAT) has introduced a new metabolic profiling
reference library for use during ion mobility mass spectrometry-based
research. The Metabolic
Profiling CCS Library includes more than 900 measurements of
collision cross-section (CCS) values, which measure the gas phase
three-dimensional shape of a molecule for an additional identification
coordinate used to confirm analytical results. The library also includes
more than 600 MS/MS spectra.
The library is included in Waters®UNIFI®
Scientific Information System, the company’s unique software
platform that combines instrument control and data analysis,
visualization, and management of both chromatography and mass
spectrometry results. The library is also available for use with Progenesis®
QI Software. The new resource was announced at the 64thAmerican Society for Mass Spectrometry (ASMS) meeting.
The Metabolic Profiling CCS Library enables research scientists to
accurately identify biomarkers in complex sample matrices when using ion
mobility separations. A collisional cross section (CCS) value is a
precise physicochemical property of an ion related to its size, shape,
and charge in the gas phase. In untargeted metabolomics studies
involving small sample amounts that are highly complex, researchers can
use CCS values in the library to confirm identifications of endogenous
metabolites and lipids showing statistically significant changes between
different sample groups.
“Metabolomics and lipidomics are critical techniques for biomarker
discovery and translational research, whether identifying endogenous
biomarkers of interest for efficacy, or understanding disease
progression. Ion mobility mass spectrometry is an enabling technology
for performing untargeted metabolomics studies where the researcher
wants to learn as much as possible about the underlying biology. Where
ion mobility increases overall chromatographic peak capacity, CCS values
improve confidence that a researcher has correctly identified a
particular metabolite/s,” commented David Heywood, senior business
development manager for Waters’ omics solutions.
The Metabolic Profiling CCS Library for UNIFI is available with the Vion™
IMS QTof and SYNAPT®
G2-Si HDMS® Systems, high-resolution mass
spectrometers that reduce the complexities of executing ion
mobility-based analyses.
When used in conjunction with Progenesis QI Software, which aids in the
identification of compounds that are significantly changing in a sample,
the technologies enable researchers in biomarker identification to
robustly and routinely mine complex samples with high coverage and
statistical rigor.
For more information: http://www.waters.com/clarity
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE: WAT) develops and manufactures advanced
analytical and material science technologies for laboratory dependent
organizations. For more than 50 years, the company has pioneered a
connected portfolio of separations science, laboratory information
management, mass spectrometry and thermal analysis systems.
Waters, UNIFI, Progenesis, Vion, SYNAPT, and HDMS are trademarks of
Waters Corporation.
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Source: Waters Corporation
Waters Corporation
Karen Haas, +1 508-482-3363
Public Relations
karen_haas@waters.com