Extending the Practicality and Enhancing the Value of Microscale
Liquid Chromatography, Better Enabling Scientists to Quantify
Hard-to-Separate Analytes in Precious Samples
MILFORD, Mass.--(BUSINESS WIRE)--Aug. 17, 2016--
WatersCorporation (NYSE: WAT) is unveiling a new line of
chromatographic fittings and a new microscale separations device at the 21stInternational Mass Spectrometry Conference. The new products enable
research scientists doing nano-to-microscale liquid chromatography (LC)
to achieve greater levels of productivity for peptide bioanalyses and
for pharmacokinetic and endogenous peptide biomarker validation studies.
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Waters ionKey/MS microscale chromatography product portfolio now includes 150 micron i.d. and 300 micron i.d. iKey tiles. (Photo: Business Wire)
High Throughput Microflow LC-MS – Delivering Greater Analytical
Sensitivity in Three Minutes or Less
The Waters® 300-micron i.d. microfluidic device, the iKeyTM
HT, is a new addition to the company’s ionKey/MSTM
microscale chromatography product portfolio. The iKey HT device is a
ceramic tile that is etched with a 300-micron i.d. channel packed with
1.7 or 1.8 micron UPLC® particles, which takes the place of a
traditional capillary column. The larger i.d. microchannel etched into
the new device allows scientists to run separations at higher flow rates
as compared to the 150 micron i.d. tile, thereby shortening run times to
three minutes or less which is comparable to the run time of a
conventional LC separation performed on a 2.1 mm i.d. column.
In
a new publication by Waters, the authors describe a study for which
1,000 injections of a crashed plasma sample containing six small
molecule analytes were run on the same prototype BEH C18 iKey
HT device (300 micron x 50 mm, 1.7 micron). The results showed a
coefficient of variation (% CV) of less than 5%, at least a 2X gain in
sensitivity over UPLC/UHPLC, and a cycle time of less than three minutes
for each sample run.1
The Waters 300 µm I.D. X 50mm (L) iKey HT separation device will be
available with the following separations media: BEH 130Å PsT C18,
1.7 micron, CSH 130Å PsT C18, 1.7 micron, and HSS T3 100Å,
1.8 micron.
IMSC 2016 attendees will get to hear more about Waters iKey HT product
line at a breakfast seminar on Wednesday, August 24 from 7 – 8 a.m. in
Waters hospitality suite #715 at the Metro Toronto Convention Centre.
The ionKey/MS
system, introduced previously by Waters, and which features a 150
micron iKey, won a top innovation award from The
Analytical Scientist magazine in 2014 and an R&D
100 Award in 2015.
For more information: http://wvmc.waters.com/imsc/imsc-product-showcase/
New ZenFit Tubing Kits and Finger-Tightened Fittings for Microscale
Chromatography Feature
Good sample preparation is extremely important but never more so than
for nano and micro-scale separations. Despite the best of intentions,
connective tubing inside the UPLC system can clog and when it does, the
remedy is to replace the clogged tubing. For those less experienced,
overtightening of the connective fittings is common and can lead to
breakage or crushing of the tubing. Waters new ZenFit™
Tubing Kits include finger-tight fittings featuring ZenFit
Connection Technology. Now, with a twist of the wrist, replacing
connective tubing has never been easier.
For more information: http://wvmc.waters.com/imsc/imsc-product-showcase/
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory dependent
organizations. For more than 50 years, the company has pioneered a
connected portfolio of separations science, laboratory information
management, mass spectrometry and thermal analysis systems.
Waters, UPLC, ionKey/MS, iKey HT, iKey, ZenFit and The Science of What’s
Possible are trademarks of Waters Corporation.
1. High Throughput Microflow LC-MS: Sensitivity Gains on a Practical
Timescale, White Paper, July 2016 Part # 720005765EN
View source version on businesswire.com: http://www.businesswire.com/news/home/20160817005234/en/
Source: Waters Corporation
Waters Corporation
Brian J. Murphy, +1 508-482-2614
Public
Relations Manager
brian_j_murphy@waters.com