Kits Simplify Sample Preparation, Offer Bioanalytical Scientists a
Standardized Route to Fast, Accurate and Precise Protein Quantification
MILFORD, Mass.--(BUSINESS WIRE)--Jan. 19, 2016--
Waters Corporation (NYSE:WAT) today introduced a new line of Waters®ProteinWorks™
Digest Kits that simplify, accelerate and standardize the LC-MS
quantification of proteins via the surrogate peptide approach. The kits
are an ideal solution for laboratories performing protein bioanalysis at
innovator and biosimilar firms, contract research organizations, disease
research centers, hospitals and university medical centers. The five
kits are now available immediately worldwide from Waters.
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Waters ProteinWorks Digest Kits simplify, accelerate and standardize the LC-MS quantification of proteins. The more efficient approach to protein bioanalysis enabled by the kits, allows research to progress faster and get life-saving drugs to market quicker. (Photo: Business Wire)
“From our collaborations with scientists, it’s clear that a better
approach to bioanalysis sample preparation is needed for therapeutic
proteins. Today's methods are fraught with variability due to a lack of
standardization,” said Mike Yelle, Vice President, Waters Consumable
Business Unit. “Our ProteinWorks Kits simplify and standardize protein
quantification workflows and shorten the time to precise and accurate
results.”
The kits are also expected to allow biopharmaceutical scientists to more
easily deploy methods to contract organizations as well as transfer
methods from one laboratory to another.
Precise Protein Digestion with ProteinWorks eXpress™ Digest Kits
ProteinWorks eXpress Digest Kits contain pre-measured, lot-traceable
reagents, a 96-tube flexible sample collection module and easy-to-follow
protocols enabling reproducible, fast digestion and accurate, sensitive
protein quantification in both immunopurified and whole,
non-immunopurified plasma and serum samples. The ProteinWorks product
portfolio includes an optional, optimized µElution™ SPE kit and protocol
designed to increase assay sensitivity, reduce matrix interferences, and
improve LC-MS system robustness.
The exceptional reproducibility of the ProteinWorks Kits suggests that a
high degree of intra- and inter-laboratory standardization is achievable
- making method transfer easier and more successful.
For more information, see Waters applications note on Infliximab
in Rat Plasma describing the speed, accuracy, precision and limits
of quantification (LOQs) achievable with ProteinWorks eXpress Digest Kit.
Protein Bioanalysis by LC-MS
Bioanalysis with liquid chromatography (LC) and mass spectrometry (MS)
determines drug concentrations in biological fluids yielding data about
the time course of a drug's action in the body.
With emphasis on the process of getting biotherapeutic proteins to
patients faster, Waters continues to focus on the needs of patients and
improving healthcare delivery with novel pre-analytic solutions and
LC-MS instrumentation that empower laboratories to tackle the complexity
and challenges of large molecule quantification.
For More Information
www.waters.com/proteinworks
www.waters.com/digest
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory dependent
organizations. For more than 50 years, the company has pioneered a
connected portfolio of separations science, laboratory information
management, mass spectrometry and thermal analysis systems.
Waters, The Science of What’s Possible, µElution, and ProteinWorks are
trademarks of Waters Corporation.
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Source: Waters Corporation
Waters Corporation
Brian Murphy, +1-508-482-2614
Corporate
Public Relations
brian_j_murphy@waters.com