New Sample Preparation Workflow Produces Exceptionally Clean
Samples for Robust and Accurate LC and LC-MS Quantification
MILFORD, Mass.--(BUSINESS WIRE)--Jan. 24, 2018--
Waters Corporation (NYSE:WAT) today introduced Waters®
Oasis® PRiME MCX Cartridges and 96-Well Plates which
selectively retain and concentrate basic compounds while removing up to
99% of phospholipids using methods that are up to twice as fast as those
for traditional mixed-mode solid phase extraction (SPE) products. With
the removal of the most abundant matrix interference, phospholipids,
from biological matrices, scientists will simplify their analyses,
improve method robustness and increase instrument uptime while getting
the accurate information they need to make informed decisions.
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Waters New Oasis PRiME MCX Cartridges and Plates Remove Phospholipids and Other Interferences from Biological Matrices (Photo: Business Wire).
“While it is accepted that sample cleanup provides many benefits, such
as fewer matrix effects and lower limits of detection, many scientists
avoid sample preparation simply because they do not have the time for
method development. They want accurate results faster with the fewest
steps possible,” said Kim Haynes, Principal Product Marketing Manager,
Chemistry Technology Center. “This is why we developed simple three- and
four–step protocols to go along with Oasis PRiME MCX that deliver
consistently and reproducibly cleaner samples faster than conventional
mixed-mode SPE methods. Ultimately, this gives scientists greater
confidence in their quantitative test results in support of clinical
trial, clinical research, forensic toxicology, food or environmental
studies.”
Oasis PRiME MCX is a mixed-mode (reversed-phase and cation exchange)
sorbent that addresses the inherent complexities in quantifying target
analytes in biological matrices like serum, plasma, whole blood, or
human and animal tissue, or food samples including milk, meat and eggs.
Furthermore, no conditioning or equilibration steps are required prior
to their use, saving scientists significant time and effort. In addition
to simplifying analytical workflows, the cleaner samples produced by
Oasis PRiME MCX give scientists the same answer time and time again by
reducing ion suppression and instrument downtime due to clogged columns
and dirty mass spectrometer ion sources. Cleaner samples also translate
into longer lasting columns.
Waters’ proprietary manufacturing processes for the cartridges and
multi-well plates are optimized to increase flow reproducibility when
using positive pressure or vacuum manifolds so that processing times are
more predictable. What’s more, for added assurance every batch of
sorbent for Oasis PRiME MCX Cartridges and Multi-Well Plates is put
through a well-defined, generic, four-step phospholipid removal protocol
during the quality control testing process.
Oasis PRiME MCX Cartridges and 96-Well Plates are now available from
Waters worldwide. Oasis PRiME MCX joins Oasis
PRiME HLB, Ostro™,
Sep-Pak®,
Oasis
HLB and Oasis
Mixed Mode IEX in Waters market leading portfolio of sample
preparation products.
For more information: www.waters.com/prime
Sample Preparation for High Quality Results
Over the last decade, analytical instrument technology has evolved to
the point where limits of detection (LODs) are as low as they have ever
been. LC-MS instruments are much more capable of detecting and
identifying minute concentrations of sample constituents than ever
before. Even so, sample constituents can go undetected and those that
aren’t detected, aren’t identified and quantified. Therefore sample
preparation has never more been more important than it is today for
getting high-quality LC-MS results.
A key to increasing the signal intensity and sensitivity of a mass
spectrometer is to remove unwanted sample components – lipids and
pigments from a blood or plasma sample for example – that interfere with
the signal response of the sample analytes being measured. The removal
of matrix interferences from samples is also a proven sure-fire way to
prolong column life and the service life of a mass spectrometer.
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE: WAT), the world's leading specialty
measurement company, has pioneered chromatography, mass spectrometry,
and thermal analysis innovations serving the life, materials, and food
sciences for nearly 60 years. With approximately 7,000 employees
worldwide, Waters operates directly in 31 countries, including 15
manufacturing facilities, and with products available in more than 100
countries.
Waters, Ostro, Sep-Pak and Oasis are trademarks of Waters Corporation.
View source version on businesswire.com: http://www.businesswire.com/news/home/20180124005091/en/
Source: Waters Corporation
Waters Corporation
Brian Murphy, 508-482-2614
Public Relations
Manager
brian_j_murphy@waters.com