News Summary:
- Waters Xevo™ MRT Mass Spectrometer employs next-generation multi-reflecting time-of-flight technology to
deliver class-leading combination of high resolution and speed without compromising analytical
performance.i
- Delivers up to 6x resolution at maximum speed and up to 2x mass accuracy of competitive
systems,ii enabling scientists to process more samples in less time for large-cohort
biomedical research and epidemiology-type studies.
- Complete workflows available for metabolomic, lipidomic, and metabolite identification enables customer
flexibility and convenience using Waters™ software, columns, and instruments for high throughput
separations, and universal data-sharing with third-party software applications.
ANAHEIM, Calif., and MILFORD, Mass., June
3, 2024 /PRNewswire/ -- 72nd ASMS Conference on Mass Spectrometry and Allied
Topics – Waters Corporation (NYSE: WAT) today unveiled the Xevo™ MRT, its highest-performing benchtop mass
spectrometer (MS), setting new standards for delivering high resolution and speed, critical for large
population and epidemiology-type studies. It builds on the innovative technology pioneered by the Waters SELECT SERIES™ MRT MS. The new Xevo MRT MS combines
the raw power and resolution speed of multi-reflecting time-of-flight (MRT) and hybrid quadrupole
time-of-flight (QTof) technologies within a flexible benchtop platform.
The Xevo MRT delivers 100K FWHM resolution at 100 Hz with sub-ppm mass accuracy for confident identification and greater
lab productivity.
"Understanding complex diseases requires analysis of thousands of samples from large human cohorts to provide
statistically valid studies. This puts increased pressure on drug discovery scientists to deliver
high-quality data in shorter run times," said Dr. Udit Batra, CEO and President of Waters Corporation. "The
Xevo MRT mass spectrometer is a next generation QTof built from the ground up to address this unmet need,
delivering high resolution and speed without compromising analytical performance. Its multi-reflecting
time-of-flight design enables simultaneous high sensitivity, high resolution, and speed in a small
footprint, accelerating time-to-results and ensuring high-quality experimental outcomes."
The Xevo MRT system delivers a class-leadingiii 100,000 full width half maximum (FWHM) resolution
at 100 Hz MS/MS scan speed and <500 parts per billion (ppb) mass accuracy. This enables deeper probing of
biologically relevant concentrations with high levels of mass accuracy, independent of acquisition rate.
"A range of mass spec approaches are available for metabolomic, lipidomic, and metabolite identification
studies, yet all require compromises to be made - either in data quality or analytical efficiency," said
Professor Perdita Barran, Chair of Mass Spectroscopy in the University of Manchester (UK) Department of
Chemistry and Director of the Michael Barber Centre for Collaborative Mass Spectrometry at the Manchester
Institute of Biotechnology. "The Xevo MRT MS is impressive technology capable of higher sample throughput
combined with extremely high precision, which can significantly advance target validation and phenotyping
studies. The increase in scan speed and data quality are critical as it can allow us to run more samples in
less time without compromising confidence in our data and we are very excited by how this is allowing us to
accelerate the development of a diagnostic test for Parkinson's Disease."
The innovative multi-reflecting time-of-flight design of the Xevo MRT MS offers scientists the power to work
at maximum resolution with high sensitivity and fast data acquisition rates. This helps ensure confident
identification of analytes across a range of samples and complex matrices and generate comprehensive and
highly accurate mass data for scientific interpretation.
Waters offers complete workflows for metabolomic, lipidomic, and metabolite identification for the Xevo MRT
MS, alongside Waters high throughput ACQUITY™ UPLC™ Systems and UPLC Column chemistries and waters_connect™ Software for data acquisition, processing, and
reporting. The system supports universal data-sharing via mzML file formats with third-party informatics
software, including popular applications from Mass Analytica™ such as its MARS, Lipostar2, and MassMetaSite
software offerings.
The Waters Xevo MRT MS is orderable today for shipment in the second half of 2024.
Additional Resources
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE: WAT), a global leader in analytical
instruments and software, has pioneered chromatography, mass spectrometry, and thermal analysis innovations
serving the life, materials, food, and environmental sciences for more than 65 years. With approximately
7,700 employees worldwide, Waters operates directly in 35 countries, including 15 manufacturing facilities,
and with products available in more than 100 countries.
Waters, Xevo, SELECT SERIES, ACQUITY, UPLC, and waters_connect are trademarks of Waters
Technologies Corporation. Mass Analytica is a trademark of Mass Spec Analytica, S.L.
Contact:
Janice Foley
Senior Public Relations Manager, Corporate Communications
Waters
Corporation
janice_foley@waters.com
+1.617.823.5555
i Estimates based on Xevo MRT MS performance comparison to competitor
instruments @100Hz @m/z 956 = 100K FWHM and <500ppb mass accuracy.
ii Xevo MRT MS
Resolution of 100K FWHM @ m/z 956 is up to 1.5x to 6x competitor instruments @100Hz; Xevo MRT Mass Accuracy
of <500ppb is 2x competitor systems @ 1ppm.
iii Xevo MRT MS Resolution of 100K FWHM @ m/z
956 is up to 1.5x to 6x competitor instruments @100Hz; Xevo MRT Mass Accuracy of <500ppb is 2x competitor
systems @ 1ppm.
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SOURCE Waters Corporation